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KMID : 0545120150250050637
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Journal of Microbiology and Biotechnology
2015 Volume.25 No. 5 p.637 ~ p.647
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Chemical Genetics Approach Reveals Importance of cAMP and MAP Kinase Signaling to Lipid and Carotenoid Biosynthesis in Microalgae
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Choi Yoon-E
Rhee Jin-Kyu
Kim Hyun-Soo
Ahn Joon-Woo
Hwang Hye-Min
Yang Ji-Won
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Abstract
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In this study, we attempted to understand signaling pathways behind lipid biosynthesis by employing a chemical genetics approach based on small molecule inhibitors. Specific signaling inhibitors of MAP kinase or modulators of cAMP signaling were selected to evaluate the functional roles of each of the key signaling pathways in three different microalgal species: Chlamydomonas reinhardtii, Chlorella vulgaris, and Haematococcus pluvialis. Our results clearly indicate that cAMP signaling pathways are indeed positively associated with microalgal lipid biosynthesis. In contrast, MAP kinase pathways in three microalgal species are all negatively implicated in both lipid and carotenoid biosynthesis.
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KEYWORD
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Microalgal signaling pathways, Lipid biosynthesis, Carotenoid biosynthesis, MAP kinase, cAMP signaling
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